Health Promoting Effect of Phyllanthus emblica and Azadiractha indica against Advanced Glycation End Products Formation

Oxidative stress is linked with inflammation, diabetic complications, and advanced glycation end products formation. Intake of flavonoid-rich foods has been reported to have a beneficial effect on human health. The aim this study was verify the therapeutic potential Phyllanthusemblica Azadiractha indica against other oxidative stress-induced complications such as inflammation using in vitro study. Ethanol extracts Phyllanthus emblica fruit pulp dried leaf were prepared investigate anti-inflammatory anti-glycating potentials. In DPPH assay, EC50 value extract P. A. found be 1532.36 ± 0.17 1380.61 0.27 µg/mL, respectively. FRAP 86.6 32.12 µg ascorbic acid/100 mg dry weight extract. maximum percentage H2O2 scavenging activity 71.30% 67.38%, Extracts showed inhibition heat-induced BSA denaturation by 62.42% 53.00%, egg albumin, 50.84%% 44.31%, hemolysis 54.44% 50.21%. Both (600 µg/mL) significantly reduced browning, structural changes, aggregation, AGEs Our biophysical studies confirmed formation inhibiting extracts. Thus, our findings confirm that these are rich source antioxidants may utilized prevent destruction biomolecules, glycation, therapy variety health problems, including inflammation. Further, combination extremely useful preventing treating problems.